Harald Steiner Selected Research

Presenilins

1/2022	Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
1/2016	Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.
1/2016	Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
6/2010	Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
10/2008	Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.
1/2008	Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
7/2007	Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
5/2004	Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.
12/2002	Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
11/2002	Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

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Harald Steiner Research Topics

Disease

62	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 06/2002
5	Amyloid Plaque 10/2008 - 12/2003
3	Neoplasms (Cancer) 01/2020 - 05/2010
3	Dementia (Dementias) 12/2019 - 03/2015
3	Carcinoma (Carcinomatosis) 01/2018 - 01/2013
1	Smith-Lemli-Opitz Syndrome 01/2021
1	Myoclonus (Nocturnal Myoclonus) 12/2019
1	Seizures (Absence Seizure) 12/2019
1	Atherosclerosis 01/2019
1	Schizophrenia (Dementia Praecox) 01/2016
1	Parkinson Disease (Parkinson's Disease) 07/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2015
1	Neoplasm Metastasis (Metastasis) 12/2014
1	Teratocarcinoma 01/2013
1	Cognitive Dysfunction 08/2009

Drug/Important Bio-Agent (IBA)

47	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022 - 06/2002
28	Proteins (Proteins, Gene)FDA Link 01/2020 - 06/2002
28	Amyloid beta-PeptidesIBA 06/2010 - 06/2002
18	Amyloid (Amyloid Fibrils)IBA 01/2020 - 04/2011
15	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 06/2002
13	Peptides (Polypeptides)IBA 01/2020 - 08/2009
12	PresenilinsIBA 01/2022 - 06/2002
8	Aspartic Acid ProteasesIBA 05/2009 - 10/2002
6	Pharmaceutical PreparationsIBA 01/2022 - 02/2010
5	AcidsIBA 06/2010 - 01/2007
4	Membrane Proteins (Integral Membrane Proteins)IBA 06/2010 - 05/2003
3	Presenilin-1IBA 01/2020 - 04/2008
3	Epithelial Cell Adhesion MoleculeIBA 01/2018 - 01/2013
2	EnzymesIBA 01/2020 - 01/2016
2	Amino Acids FDA Link 12/2019 - 01/2016
2	4- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA 01/2015 - 01/2014
1	MicellesIBA 01/2022
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2022
1	SteroidsIBA 01/2021
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2020
1	Membrane LipidsIBA 01/2020
1	Donepezil (Aricept)FDA LinkGeneric 12/2019
1	LectinsIBA 01/2019
1	Oxidized LDL ReceptorsIBA 01/2019
1	Bexarotene (LGD1069)FDA Link 01/2018
1	valylleucineIBA 01/2016
1	AntigensIBA 10/2015
1	SynucleinsIBA 07/2015
1	Glycoproteins (Glycoprotein)IBA 01/2013
1	Amiodarone (Amiodarona)FDA LinkGeneric 06/2010
1	Bepridil (Vascor)FDA Link 06/2010
1	Biomarkers (Surrogate Marker)IBA 07/2009
1	Protein Sorting Signals (Signal Peptide)IBA 05/2009
1	carprofen FDA Link 12/2006
1	Cadherins (E-Cadherin)IBA 11/2002
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 11/2002
1	Notch ReceptorsIBA 11/2002